Pitt Pediatrics congratulates Amr Sawalha, MD for his recent publication in The Journal of Clinical Investigation (JCI) titled “Rheumatoid factor production is genetically and molecularly distinct from rheumatoid arthritis”.
Rheumatoid factor (RF) autoantibodies are highly prevalent, yet the molecular determinants of RF development and its progression to rheumatoid arthritis (RA) remain poorly understood. Here, Sawalha defines the genetic, phenotypic, and molecular architecture of RF and its progression to RA.
Through his research, Sawalha found that RF production is governed by HLA class II and B cell regulatory loci, associated with mucosal inflammation, and is genetically and molecularly distinct from RA.
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